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新生儿中性粒细胞减少症又分为早发型中性粒细胞减少症及晚发型中性粒细胞减少症,病因可大致分为粒细胞生成减少、破坏增多、附着于微血管内皮系统、在脾脏破坏过多或几种原因混合所致.中性粒细胞减少症常常伴随感染风险的增加,有时是某些罕见严重疾病的提示,早期诊断及合适的治疗有利于改善预后.本文对新生儿中性粒细胞减少症的发病机制及诊治进展作一综述.“,”Neonatal neutropenia is classified into early-onset and late-onset neutropenia.Causes of neutropenia include decreased production,increased destruction,margination in the microvascular endothelium,sequestration in the spleen,or a combination of mechanisms.Neutropenia often accompanied by an increased risk of bacterial infection,and sometimes it may be a hint of some rare severe diseases.In this article,we review advances in classification,pathogenesis,diagnosis and treatment of neonatal neutropenia.