目的　了解惠州地区幽门螺杆菌感染的流行病学资料。方法　对惠州沿海和非沿海地区的六个乡镇 2 3 77名各年龄组自然人群进行前瞻性幽门螺杆菌感染血清学调查。结果　幽门螺杆菌总感染率为4 5 6% ,感染率明显与年龄、居住地、饮水习惯、居住密度、饲养家禽、使用抗生素等因素相关。结论　惠州地区属幽门螺杆菌感染低发区 ,幽门螺杆菌既可通过密切接触传播 ,又可通过粪 -口等多种途径传播。 Objective To understand the epidemiological data of Helicobacter pylori infection in Huizhou area. Methods A prospective serological investigation of Helicobacter pylori infection was performed in 2 3 77 natural populations from 6 townships in coastal and non-coastal areas of Huizhou. Results The total infection rate of Helicobacter pylori was 45.6%. The infection rate was significantly related to age, residence, drinking habits, residential density, feeding of poultry and use of antibiotics. Conclusion In the low incidence area of ​​Helicobacter pylori infection in Huizhou area, Helicobacter pylori can be transmitted by close contact and spread through fecal-oral route.