论文部分内容阅读
本研究采用鼠伤寒沙门氏菌营养缺陷型回复突变试验(Ames试验)检测根管药物控释系统的遗传毒性。结果揭示:氯已锭控释药核,甲硝唑控释药核,包膜及牙胶等各种受试材料在4种试验菌株均获得阴性结果。可以认为根管药物控释系统无致突变致癌作用,具有临床应用的安全性。
In this study, Salmonella typhimurium auxotrophic mutation test (Ames test) to detect the root canal drug-controlled release system of genotoxicity. The results revealed that all the tested materials such as chlorhexidine controlled release drug core, metronidazole controlled release drug core, capsule and dentin obtained negative results in the four tested strains. It can be considered that the root canal drug controlled release system has no carcinogenic effect on mutation and has clinical application safety.