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目的探讨妊娠期高血压疾病(HDCP)患者凝血指标和血小板参数的改变及其临床意义。方法采用全血细胞分析仪和全自动血凝分析仪分别对50例HDCP患者(HDCP组)与90例健康妊娠晚期孕妇和100例健康非孕妇女(对照组)的血液标本进行凝血酶凝结时间(TT)、凝血酶原时间(PT)、凝血活酶时间(APTT)、纤维蛋白原(FIB)和血小板相关参数及血小板压积(PCT)、血小板计数(PLT)、平均血小板体积(MPV)、血小板体积分布宽度(PDW)的检测和统计分析。结果HDCP组的PT、FIB、PLT、MPV、PCT、PDW分别为(11.65±1.35)s、(4.21±0.86)g/L、(197.2±71.2)×109/L、(11.1±1.8)f L、(0.11±0.46)%、(20.6±1.4)%,与对照组的(13.00±0.95)s、(2.71±0.66)g/L、(207±68.2)×109/L、(10.1±1.7)f L、(0.13±0.32)%、(18.6±1.3)%比较差异有统计学意义(P<0.05);妊娠晚期组PT、APTT、FIB、PLT为(12.02±0.92)s、(25.49±4.36)s、(3.62±0.76)g/L、(198.5±70.2)×109/L与对照组比较差异有统计学意义(P<0.05);HDCP组PT、APTT、FIB、MPV、PDW与妊娠晚期组相比差异有统计学意义(P<0.05)。结论检测血小板参数和凝血指标有助于早期发现妊娠期高血压疾病患者和及时发现血栓前状态,可有效预防血栓和子痫等病症的发生。
Objective To investigate the changes of coagulation parameters and platelet parameters in patients with gestational hypertension (HDCP) and its clinical significance. Methods Blood samples were collected from 50 HDCP patients (HDCP group) and 90 healthy pregnant women and 100 healthy non-pregnant women (control group) by using hematology analyzer and automatic hemagglutination analyzer. Thrombin coagulation time TT, PT, APTT, fibrinogen (FIB) and platelet parameters, platelet pressure (PCT), platelet count (PLT), mean platelet volume (MPV) Detection and Statistical Analysis of Platelet Volume Distribution Width (PDW). Results The mean PT, FIB, PLT, MPV, PCT and PDW in HDCP group were (11.65 ± 1.35) s, (4.21 ± 0.86) g / L and (197.2 ± 71.2) × 109 / L , (0.11 ± 0.46)% and (20.6 ± 1.4)% respectively, which were significantly higher than those in control group (13.00 ± 0.95) s, (2.71 ± 0.66) g / L and (207 ± 68.2) The levels of PT, APTT, FIB and PLT in the third trimester of pregnancy were (12.02 ± 0.92) s, (25.49 ± 4.36) and ), (3.62 ± 0.76) g / L and (198.5 ± 70.2) × 109 / L, respectively. There was significant difference between the HDCP group and the control group (P <0.05) The difference was statistically significant (P <0.05). Conclusion The detection of platelet parameters and coagulation indexes can help early detection of patients with hypertensive disorder complicating pregnancy and timely detection of prethrombotic state, which can effectively prevent the occurrence of thrombosis and eclampsia.