由于Walter Reed军队研究所的大力开发并大范围用于抗疟的发现,乙基奎宁已经成功发展成为磷酸伯氨喹(在药典中首选药)的代用药。临床前期以及临床应用结果表明该药对恶性疟和间日疟具有可能的抗疟作用。乙基奎宁是磷酸伯氨喹类的合成品,即在喹啉环中的2个点上加入甲氧级,4个点上加入甲基,5个点上用三氟甲酚基代替。在英国进行了啮 Due to the intensive development of the Walter Reed Army Institute and its widespread use in the fight against malaria, ethylquinine has been successfully developed as a surrogate for primaquine phosphate, the drug of choice in the Pharmacopoeia. Preclinical and clinical application results show that the drug has a potential anti-malarial effect against falciparum malaria and Plasmodium vivax. Ethyl quinine is a synthetic product of primaquine phosphate, that is, a methoxy group is added at two points in the quinoline ring, methyl is added at four points, and trifluoromethyl is substituted at five points. Engaged in England