人血清低密度脂蛋白(LDL)在体内、外可与葡萄糖发生糖基化修饰。糖基化水平与葡萄糖浓度正相关。糖尿病患者,尤其是血糖控制不良者,LDL糖基化水平显著高于正常人,而且与血脂水平变化密切相关。糖基化LDL的受体途径代谢受阻,体内清除减慢;还发现有免疫厚性,易被单核巨噬细胞大量摄取而造成细胞内脂质堆积。 Human serum low density lipoprotein (LDL) can be glycosylated with glucose in vitro and in vivo. Glycosylation level is positively correlated with glucose concentration. Diabetics, especially those with poor glycemic control, have significantly higher levels of LDL-glycosylation than normal subjects and are closely associated with changes in blood lipid levels. The receptor pathway of glycosylated LDL blocked the metabolism and slowed the clearance of the body. It was also found to be immunocompromised and easy to be ingested by macrophages in large quantities to cause the accumulation of intracellular lipid.