Absolute one-handed chiral quinoline tetramers andoctamers containing different oxazolylanilines at the C-terminus have been synthesized. The absolute one-handed sense and diastereomeric excess values werevaluedby 1H NMR.X-raycrystaldiffractionandCDstudiesrevealthatthe S-oxazolylanilinealways induces a P-handed helicity and the absolute helicity is driven by the stable three-center hydrogen bonding between protons in the amide and N atoms in oxazolylaniline and adjacent quinoline ring. CPL investigations demonstrated that S-CQn-a ～d are CPL active and its glum values are dependent on its length. Interestingly, the sizes of the substituents in the chiral centers are different, however, they exert no effect on the dissymmetric factors gabs and glum of quinoline oligoamide foldamers.