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目的探讨米非司酮治疗子宫肌瘤的临床效果。方法65例确诊为子宫肌瘤患者,从月经来潮第1天开始口服米非司酮12.5mg/d,连服3个月为一疗程,用药一疗程后停药。用药前后以彩色多普勒超声测量子宫及肌瘤大小、测定血清雌二醇孕酮血常规肝功能。结果治疗期间所有患者出现闭经,一疗程结束后,子宫体积及肌瘤平均体积缩小,E2、P水平亦有显著下降。停药随访一年,30例患者肌瘤增大。结论米非司酮治疗子宫肌瘤有一定疗效,但停药后易复发。
Objective To investigate the clinical efficacy of mifepristone in treating uterine fibroids. Methods Totally 65 patients with uterine fibroids were diagnosed as uterine fibroids. Mifepristone 12.5 mg / d was given orally on the first day of menstrual cramps. Before and after treatment with color Doppler ultrasound measurement of uterine and fibroid size, determination of serum estradiol and progesterone blood routine liver function. Results All patients had amenorrhea during the treatment. After one course of treatment, the average volume of uterine fibroids and fibroids decreased and the levels of E2 and P decreased significantly. One year after discontinuation, fibroids increased in 30 patients. Conclusion Mifepristone treatment of uterine fibroids have a certain effect, but easy to relapse after stopping.