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目的:观察α受体阻滞剂坦索罗辛配合ESWL术后的辅助排石作用。方法:将2009年8月～2011年9月收治193例肾结石患者随机分为两组,治疗组除常规治疗外,每日清晨口服坦索罗辛0.4mg。观察排石率、结石平均排出时间、肾绞痛发生率及止痛药使用率等,所有患者每周复查B超及KUB。结果:治疗组的排石率为95.8%,而对照组为78.4%,结石平均排出时间分别为4.2及9.6天,两组肾绞痛发生率及止痛药使用率等均差异有统计学意义(P<0.05)。治疗组中输尿管结石残留、石街形成、需再次ESWL或者输尿管镜检查术等均显著减少。结论:α受体阻滞剂坦索罗辛配合ESWL术可明显提高结石排出率,减少排石时间,缓解治疗期间肾绞痛的发生,效果好于单纯ESWL。
OBJECTIVE: To observe the effect of tamsulosin, an α receptor blocker, on the auxiliary row of stone after ESWL. Methods: 193 patients with nephrolithiasis from August 2009 to September 2011 were randomly divided into two groups. The treatment group was given tamsulosin 0.4 mg daily in the morning except for routine treatment. Observe the rate of row of stone, the average discharge time of stone, the incidence of renal colic and the use of painkillers, etc., all patients weekly review of B- and KUB. Results: The rate of stone removal was 95.8% in the treatment group and 78.4% in the control group. The mean time to stone discharge was 4.2 and 9.6 days, respectively. The incidence of renal colic and the painkiller utilization in the two groups were significantly different P <0.05). In the treatment group, residual ureteral stones and stone street were formed, and ESWL or ureteroscopy was required again. CONCLUSION: Tamsulosin plus estrin blockers combined with ESWL can significantly improve the rate of stone excretion, reduce the time of stone discharging and relieve the occurrence of renal colic during treatment, which is better than ESWL alone.