论文部分内容阅读
目的 :探讨血清前列腺特异性抗原 (PSA)在前列腺癌 (PC)患者手术前后的临床应用价值。方法 :采用放射免疫分析 (RIA)对 35例正常人及 4 8例PC患者在手术前后进行血清PSA测定。结果 :术前检测PC组 4 6例阳性 ,PC与正常组PSA测定值分别为 5 4 4 7± 4 3 5 2ng/ml与 1 72± 1 14ng/ml(p <0 0 0 1) ,对PC检测的灵敏度 95 8% ,特异性 95 %。其中 2 3例患者在确诊PC前患有前列腺增生 (BPH)时血清PSA水平为 6 2 3±2 94ng/ml,在确诊PC时血清PSA水平上升至 5 6 84± 4 8 12ng/ml(p <0 0 0 1)。术后观察PSA在 3～ 6个月降为正常 ,患者均已生存 4年以上 ,一般情况良好 ,术后PSA无明显变化者均在 2年内先后死亡 ,其中 8例为全身骨转移。结论 :血清PSARIA检测对PC术前诊断及术后评估患者的预后具有良好的应用价值
Objective: To investigate the clinical value of serum prostate specific antigen (PSA) in patients with prostate cancer (PC) before and after surgery. Methods: The serum PSA levels of 35 normal subjects and 48 patients with PC were measured by radioimmunoassay (RIA) before and after operation. Results: Preoperative detection of PC group 46 positive cases, PC and normal group PSA measured values were 5447 ± 4352ng / ml and 72214ng / ml (p <0 001), the The sensitivity of PC detection 95 8%, specificity 95%. Serum PSA levels were 623 ± 2 94 ng / ml in 23 patients with benign prostatic hyperplasia (BPH) before diagnosis of PC, and increased to 5684 ± 481 ng / ml at the time of diagnosis of PC (p <0 0 0 1). Postoperative observation of PSA decreased to normal in 3 to 6 months, the patients have survived more than 4 years, generally good, no significant change in postoperative PSA were in 2 years have died, of which 8 cases of systemic bone metastases. Conclusion: The detection of serum PSARIA has a good value in the diagnosis of PC and the prognosis of postoperative patients