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目的 :制备用于治疗老年性阴道炎的复方蛇床子泡腾栓 ,并制订质量控制指标。方法 :采用 95 %乙醇提取有效成分 ,对有效成分进行增溶后再根据处方将其制成泡腾栓 ,采用 UV /VIS- 75 0 1紫外可见分光光度计测定制剂中血竭的含量。结果 :本制剂泡沫量大、泡沫持续时间长、泡沫均匀细腻 ,且 p H与阴道生理 p H较接近 ,制剂中含量测定方法可靠。结论 :制剂中药物释放快、药效持续时间长 ,是用于治疗老年性阴道炎的较好剂型 ,所制订的质量控制方法可行。
Objective : To prepare compound Cnidium Effervescent Suppository for the treatment of senile vaginitis and to establish quality control indicators. Methods : 95 % ethanol was used to extract the active ingredients. The active ingredients were solubilized and then made into effervescent plugs according to the prescription. The content of dragon’s blood in the preparation was determined by UV/VIS-7501 UV-Vis spectrophotometer. Results: The preparation has a large amount of foam, a long foam, a uniform and delicate foam, and p H is closer to the physiological pH of the vagina. The method for determining the content of the preparation is reliable. Conclusion: The rapid drug release and long-lasting drug efficacy in the preparations are the preferred dosage forms for the treatment of senile vaginitis. The quality control methods developed are feasible.