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本文报告外科术中病人持续静滴普鲁卡因(PROC)的体内过程特点及其代谢产物对氨基苯甲酸(PABA)血浆内药代动力学过程以及对血液pH值及碱储的影响。用反相高效液相色谱紫外法测定仪测定血浆内普鲁卡因及对氨基苯甲酸浓度。用BGM血气分析血液pH值及碱储值,7名外科手术病人依次以1,0.7及0.5mg/kg/min的速度静滴普鲁卡因各1h后测得普鲁卡因其药时曲线表明:随着静滴普鲁卡因的时间延长,血浆内普鲁卡因浓度逐渐上升,并于停滴后一段时间内维持在较高水平,此发现与其它文献报道不相同;故本文进一步研究了普鲁卡因的药代动力学过程及病人血液pH值及碱储值的变化,结果表明;静滴普鲁卡因后由血浆胆碱酯酶水解产生的对氨基苯甲酸可使病人出现代谢性酸中毒,显著消耗碱储(p<0.01),而且碱储消耗的动态过程与普鲁卡因的过程显著相关(p<0.05)。
This article reports on the in vivo process characteristics of sustained intravenous procaine (PROC) and the pharmacokinetics of its metabolite p-aminobenzoic acid (PABA) plasma as well as its effect on blood pH and alkali storage. Determination of procaine and p - aminobenzoic acid in plasma by reversed - phase high performance liquid chromatography with ultraviolet detector. BGM blood gas analysis of blood pH and alkali stored value, seven surgical patients followed by 1, 0.7 and 0.5mg / kg / min intravenous procaine 1h after the measured procaine drug-resistant curve The results showed that the concentration of procaine in plasma increased gradually with the prolongation of intravenous procaine and maintained at a high level for a while after stopping drip, which was not the same as that reported in other literatures. Therefore, The pharmacokinetics of procaine and changes of blood pH value and alkali storage value of the patients were studied. The results showed that p-aminobenzoic acid produced by plasma cholinesterase after intravenous infusion of procaine could make the patients Metabolic acidosis occurred, significantly depleting alkali stores (p <0.01), and the dynamic process of alkali storage was significantly associated with procaine (p <0.05).