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目的探讨坦索罗辛在治疗输尿管下段结石中的临床疗效。方法将86例输尿管下段结石(直径4～9 mm)患者随机分为两组,每组各43例。对照组给予肾石通颗粒4 g/次,2次/d。治疗组级予肾石通颗粒4 g/次,2次/d,加坦索罗辛0.4 mg/次,1次/d。所有患者治疗观察期不超过2周。观察排石率、排石时间、镇痛剂使用率等。结果对照组排石率为40%(17/43),治疗组排石率为74%(32/43),两组比较差异有统计学意义(P<0.05)。平均排石时间对照组和治疗组分别为(10.5±2.0)d和(6.2±1.7)d,两组比较差异有统计学意义(P<0.05)。2周内再发肾绞痛需要镇痛治疗者对照组和治疗组分别为9例(21%)和3例(7%),两组比较差异有统计学意义(P<0.05)。两组患者观察期内均未发现明显副作用。结论应用坦索罗辛在治疗输尿管下段结石的辅助排石方面安全、有效,可有效提高结石排出率、缩短排石时间,减少镇痛剂使用率。
Objective To investigate the clinical efficacy of tamsulosin in the treatment of lower ureteral calculi. Methods 86 patients with lower ureteral calculi (diameter of 4 ~ 9 mm) were randomly divided into two groups, each group of 43 cases. The control group was given kidney stone particles 4 g / time, 2 times / d. Treatment group grade to kidney stone particles 4 g / time, 2 times / d, plus tamsulosin 0.4 mg / time, 1 time / d. All patients treated for no more than 2 weeks observation period. Observe the rate of row of stone, row of stone time, analgesic usage and so on. Results The control group had a rate of 40% (17/43) and the treatment group had a rate of 74% (32/43). The difference between the two groups was statistically significant (P <0.05). The average time of stone discharging was (10.5 ± 2.0) d and (6.2 ± 1.7) days respectively in the control group and the treatment group, with significant difference between the two groups (P <0.05). There were 9 cases (21%) and 3 cases (7%) in control group and treatment group with analgesic treatment of recurrent renal colic in 2 weeks. The difference between the two groups was statistically significant (P <0.05). No significant side effects were observed in both groups during the observation period. Conclusion The application of tamsulosin in the treatment of lower ureteral stones in the auxiliary row of stones safe and effective, which can effectively improve the rate of stone discharge, shorten row time, reduce the use of analgesics.