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目的研究健康绝经后女性血清前脂肪细胞因子1(Pref-1)水平与骨密度(BMD)的相关性。方法在120例健康绝经后女性中进行Pref-1和BMD水平检测,记录受试者基本信息。Pref-1水平和BMD的相关性使用Pearson相关性分析。以Pref-1水平、年龄、更年期时间、体质量指数(BMI)和收缩期血压为自变量,以BMD为因变量,进行多元回归分析。根据是否有骨折病史,进行亚组分析,检测BMD与Pref-1水平的相关性。结果受试者平均年龄为(59.20±7.90)岁,平均BMI为(24.60±3.80)kg/m2,21例(17.5%)患者有骨质疏松性骨折病史。多元回归分析未见血清Pref-1水平与BMD存在显著相关(腰椎R~2=0.034,P=0.11,股骨颈R~2=0.016,P=0.87,全髋R~2=0.045,P=0.10)。亚组分析亦未见血清Pref-1水平与BMD存在显著相关(P>0.05)。结论健康绝经后女性血清Pref-1水平与BMD未见显著相关性。
Objective To investigate the correlation between pref-1 level and bone mineral density (BMD) in healthy postmenopausal women. Methods Pref-1 and BMD levels were measured in 120 healthy postmenopausal women and the basic information of the subjects was recorded. Pearson correlation analysis of Pref-1 levels and BMD was used. The Pref-1 level, age, menopause time, body mass index (BMI) and systolic blood pressure were used as independent variables, and BMD was used as a dependent variable for multiple regression analysis. According to whether there is a history of fracture, a subgroup analysis was performed to determine the correlation between BMD and Pref-1 levels. Results The average age of the subjects was (59.20 ± 7.90) years, the mean BMI was (24.60 ± 3.80) kg / m 2 and the history of osteoporotic fracture was found in 21 patients (17.5%). Multiple regression analysis showed no significant correlation between serum Pref-1 level and BMD (lumbar R ~ 2 = 0.034, P = 0.11, femoral neck R ~ 2 = 0.016, P = 0.87, total hip R ~ 2 = 0.045, P = 0.10 ). Subgroup analysis also did not see serum Pref-1 levels and BMD significant correlation (P> 0.05). Conclusion There is no significant correlation between serum Pref-1 level and BMD in healthy postmenopausal women.