论文部分内容阅读
目的 探讨隆突性皮肤纤维肉瘤临床及病理学与肿瘤术后复发、预后的关系。方法 分析２２例患者临床与病理组织学特点。结果 肿瘤以青壮年为多见，发病部位躯干多于其他部位，临床上具有病程长、生长缓慢、局部切除易复发、转移罕见等特点。组织学特征为梭形瘤细胞及胶原纤维构成车辐状结构。首发病例有典型车辐状结构，核分裂相少，复发病例的车辐状结构不明显，核分裂相增多。随访术后复发与无复发病例内均可见核分裂，肿瘤体积大小无明显差异，肿块距皮肤切缘均＜ ２ ｃｍ，切缘阳性或阴性的病例均有复发。结论 肿瘤的复发与肿瘤体积大小及核分裂相多少无明显相关性，而与手术切除范围局限有关。
Objective To investigate the relationship between the clinical and pathological features of tubulid dermatofibrosarcoma and the recurrence and prognosis of the tumor. Methods The clinical and histopathological features of 22 patients were analyzed. Results The tumors were more common in young and middle-aged adults. The incidence of the disease was more than that of the other parts of the body. Clinically, it had the characteristics of long course, slow growth, local excision and recurrence and rare metastasis. Histological features of spindle cells and collagen fibers form a car-like structure. The first case of a typical car spoke structure, mitotic phase less recurrence of the car radial structure is not obvious, increased nuclear fission phase. There was no significant difference in the size of the tumors between the recurrent and non-recurrent cases. The tumor resection margin was less than 2 cm, and the positive or negative margins were all recurred. Conclusions There is no significant correlation between the tumor recurrence and the size of the tumor and the number of mitotic phases, which is related to the limited scope of the surgical resection.