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卟啉病为一组血红素合成代谢途径障碍所致的疾病,受损的肾功能常可干扰卟啉的排泄和导致血浆的增高。本文旨在研究正常人血浆和尿中卟啉的浓度,了解肾脏在卟啉代谢中的作用及卟啉病和卟啉病性慢性肾衰(CRF)。应用敏感定量的HPLC萤光法测定正常人,迟发型皮肤卟啉病(PCT),先天性红细胞血卟啉病(CEP),遗传性粪卟啉病(HCP)患者血浆和尿中的卟啉含量,对10例CRF患者于透析前后分别检测血浆卟啉浓度并与正常组进行对照。结果:10例CRF血透患者血浆尿卟啉升高,其中4例血浆7-羧基卟啉升高,2例血浆粪卟啉升高且经血透
Porphyromonas is a disorder caused by a heme-biosynthetic pathway, and impaired renal function can often interfere with porphyrin excretion and lead to increased plasma levels. The purpose of this paper is to study the concentrations of porphyrins in plasma and urine of normal individuals and to understand the role of the kidney in the metabolism of porphyrins and porphyria and porphyria-induced chronic renal failure (CRF). Determination of porphyrin in plasma and urine of normal people, delayed type porphyria (PCT), congenital erythrocytic porphyria (CEP), hereditary protoporphyrinosis (HCP) patients by sensitive fluorescent quantitative method Content, 10 cases of CRF patients were measured before and after dialysis plasma porphyrin concentration and compared with the normal group. Results: 10 cases of CRF hemodialysis patients with elevated urinary porphyrin, including 4 cases of plasma 7-carboxy-porphyrin increased, 2 cases of plasma coproporphyrin and hemodialysis