论文部分内容阅读
目的分析我院抗菌药物不良反应发生的特点及规律,为临床合理用药提供依据。方法收集分析我院2008年1月—2012年12月各科室上报的抗菌药物不良反应(ADR)125例,按患者年龄、性别、抗菌药物种类及使用率、ADR临床表现等方面进行分类统计和分析。结果 125例抗菌药物不良反应中,中老年人发生率较高,占52.0%。男59例,女66例。静脉给药导致不良反应最多为94.4%。引起ADR的抗菌药物以头孢菌素类居首48.8%,其次为喹诺酮类24.0%和青霉素类16.8%。主要不良反应症状为消化系统损害及皮肤损害。在不良反应轻重程度上,轻度者占74.8%。发生不良反应的患者转归较好,其中76.4%患者治愈,23.6%的患者经采取有效措施后好转,无死亡病例。结论临床应重视抗菌药物所致不良反应,加强ADR监测,减少或避免抗菌药物ADR的发生。
Objective To analyze the characteristics and rules of adverse reactions of antimicrobial agents in our hospital and provide the basis for clinical rational drug use. Methods A total of 125 cases of ADR reported in our hospital from January 2008 to December 2012 were collected and analyzed. According to the age, gender, antibacterial type and usage rate, ADR clinical manifestations and other aspects analysis. Results Among the 125 cases of adverse reactions of antimicrobial agents, the incidence of middle-aged and elderly was higher, accounting for 52.0%. 59 males and 66 females. Intravenous administration resulted in up to 94.4% of adverse reactions. The antibacterial drugs that cause ADR topped 48.8% with cephalosporins, followed by quinolones 24.0% and penicillins 16.8%. The main adverse reaction symptoms are digestive system damage and skin damage. In the severity of adverse reactions, mild accounted for 74.8%. Patients with adverse reactions had a better prognosis, of which 76.4% patients were cured, 23.6% of patients improved after taking effective measures, no deaths. Conclusion Clinical should pay attention to adverse reactions caused by antimicrobial agents, strengthen the monitoring of ADR, reduce or avoid the occurrence of antimicrobial agents ADR.