论文部分内容阅读
吗啡用于治疗晚期肿瘤患者的严重疼痛为时已久。在晚期肿瘤患者,分解代谢和器官转移可改变机体对药物的处置。为此,作者研究了吗啡在癌症患者体内的动力学。受试者为7例各种癌症患者,5女2男,年龄在49～79岁。给受试者缓慢静脉注射4mg(相当于0.037～0.066mg/kg)吗啡,两天后口服一次吗啡20～30mg(相当于0.231～0.495mg/kg)。分别于静脉注射和口服后不同时间取血,用气相层析法测定血清吗啡浓度。
It has been a long time since morphine was used to treat severe pain in patients with advanced cancer. In advanced cancer patients, catabolism and organ metastasis can alter the body’s treatment of the drug. To this end, the authors studied the kinetics of morphine in cancer patients. Subjects for 7 cases of various cancer patients, 5 women and 2 men, aged 49 to 79 years. Subjects were given a slow intravenous injection of 4 mg morphine (equivalent to 0.037 to 0.066 mg / kg) and 20 to 30 mg (equivalent to 0.231 to 0.495 mg / kg) of morphine orally two days later. Blood samples were collected at different times after intravenous injection and oral administration, respectively, and serum morphine concentrations were determined by gas chromatography.