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肝癌(HCC)的发生与乙肝病毒(HBV)感染有关,这已从大量临床和流行病学资料,以及分子生物学研究发现的HCC中HBVDNA的整合得到依据,但HBV在HCC形成中的作用机制尚未明了。1985年对HBVDNA的序列分析,发现存在4个框架(ORF)C、S、P和X,推则X-ORF为编码154个氨基酸的多肽,但并不了解这一多肽的功能。近年对X基因和及其表达产物的研究十分活跃,尤其是它在HCC中的表达。近年的一系列研究表明:(1)X蛋白对其基因的enhancer以及其他基因的Promotor都有转录激活作用。(2)X基因是HBV在HCC中整合的一段主要基因区,整合后的重组基因有转录
The occurrence of hepatocellular carcinoma (HCC) is associated with hepatitis B virus (HBV) infection, which has been based on a large number of clinical and epidemiological data, as well as the integration of HBV DNA in HCC found in molecular biology research. However, the mechanism of HBV in HCC formation Not yet clear. The sequence analysis of HBV DNA in 1985 revealed the existence of four frameworks (ORFs) C, S, P, and X. When the X-ORF was encoded as a polypeptide of 154 amino acids, the function of this polypeptide was not known. In recent years, the study of X gene and its expression products has been very active, especially its expression in HCC. A series of recent studies have shown that: (1) X protein has transcriptional activation of its gene’s enhancer and other gene’s promoter. (2) The X gene is a major gene region of HBV that integrates in HCC, and the integrated recombinant gene has transcription