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目的:探讨冠心病患者血清纤维蛋白原和血小板高反应性与经皮冠脉介入术围术期心肌梗死发生的相关性。方法:以201 1年至2012年12月收治的79例拟行经皮冠脉介入术的急性冠脉综合症患者为研究对象,观察其血清纤维蛋白原和血小板高反应性(5uM ADP诱导的血小板聚集率>50%)与围术期心肌梗死发生的相关性。结果:糖尿病、血小板高反应性和血纤维蛋白原与围术期心肌梗死具有相关性,多因素回归分析显示,血小板高反应性和血清纤维蛋白原水平是围术期心肌梗死的独立危险因素(P<0.05)。结论:冠心病患者血清纤维蛋白原水平和血小板高反应性与经皮冠脉介入术发生围术期心肌梗死有明显相关性。
Objective: To investigate the correlation between serum fibrinogen and platelet hyperreactivity in patients with coronary heart disease and perioperative myocardial infarction after percutaneous coronary intervention. Methods: A total of 79 patients with acute coronary syndrome who underwent percutaneous coronary intervention from 201 to December 2012 were enrolled in this study. Serum fibrinogen and platelet hyperreactivity (5uM ADP-induced platelet Aggregation rate> 50%) and the incidence of perioperative myocardial infarction. Results: There was a correlation between diabetes mellitus, platelet hyperreactivity and fibrinogen and perioperative myocardial infarction. Multivariate regression analysis showed that platelet hyperreactivity and serum fibrinogen level were independent risk factors of perioperative myocardial infarction P <0.05). Conclusion: Serum fibrinogen level and platelet reactivity in patients with coronary heart disease are significantly correlated with perioperative myocardial infarction in percutaneous coronary intervention.