使用药物防治疟疾是消灭疟疾综合措施中的重要一环。自从发现奎宁能治疗疟疾以来,曾从奎宁的结构改造方面寻找出氯喹、伯喹等有效抗疟药。1959年在哥伦比亚发现有抗氯喹的恶性疟原虫后,世界各国更致力于寻找新的抗疟药。但迄今还没有找到较理想的新抗疟药。现在常用的抗疟药主要是氯喹、奎宁、伯喹和乙胺嘧啶。 The use of drugs to combat malaria is an important part of the comprehensive malaria elimination program. Since it was discovered that quinine can treat malaria, effective antimalarial drugs such as chloroquine and primaquine have been sought from the structural transformation of quinine. After the discovery of chloroquine-resistant Plasmodium falciparum in Colombia in 1959, countries in the world are still more committed to finding new antimalarial drugs. However, so far no ideal new antimalarial drug has been found. Now commonly used anti-malarial drugs are mainly chloroquine, quinine, primaquine and pyrimethamine.