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目的:探讨PI3K和CyclinD1蛋白表达在良性子宫内膜增生、子宫内膜上皮内瘤变(EIN)、子宫内膜样腺癌发生、发展中的作用。方法:选取增殖期子宫内膜10例、良性增生性子宫内膜30例(包括单纯性增生和复杂性增生),子宫内膜上皮内瘤变30例,子宫内膜样腺癌20例,应用免疫组织化学法检测各组中PI3K和CyclinD1蛋白的表达,分析其表达水平的变化。结果:PI3K和CyclinD1在增殖期子宫内膜、良性增生性子宫内膜、EIN和子宫内膜样腺癌中表达依次增高,组间差异具有统计学意义(H=46.64,P<0.01;H=44.96,P<0.01);PI3K与CyclinD1表达呈正相关(r=0.682,P<0.01),且二者与组别及年龄均呈正相关(P<0.01)。结论:PI3K高表达可能是通过诱导和调控CyclinD1的过表达实现的,PI3K和CyclinD1可能参与了子宫内膜恶性转化的过程。
Objective: To investigate the role of PI3K and CyclinD1 in the pathogenesis of benign endometrial hyperplasia, endometrial intraepithelial neoplasia (EIN) and endometrial adenocarcinoma. Methods: Ten cases of proliferative endometrium, 30 cases of benign proliferative endometrium (including simple hyperplasia and complex hyperplasia), 30 cases of endometrial intraepithelial neoplasia and 20 cases of endometrial adenocarcinoma were selected Immunohistochemistry was used to detect the expression of PI3K and CyclinD1 in each group, and the changes of their expression were analyzed. Results: The expressions of PI3K and CyclinD1 in proliferating endometrium, benign proliferative endometrium, EIN and endometrioid adenocarcinoma were significantly increased (P <0.01). The difference between the two groups was statistically significant (H = 46.64, P <0.01; H = 44.96, P <0.01). There was a positive correlation between the expression of PI3K and CyclinD1 (r = 0.682, P <0.01). Conclusion: The high expression of PI3K may be induced by overexpression of CyclinD1, and PI3K and CyclinD1 may be involved in the process of malignant transformation of endometrium.