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氨噻肟头孢菌素(Cefotaxime,代号HR-756,商品名Claforan)是一个新的、第三代头孢菌素,具有广谱、低毒、高效、耐酶并易于生产等特点。1977年由联邦德国赫斯特(Hoechst)公司发现并已发展成为国际公认的优秀产品。我国于1982年由四川抗菌素工业研究所、四川长征制药厂和东北制药总厂联合研制成功。本文报告国产氨噻肟头孢菌素体外抗菌作用研究结果。比较了国产氨噻肟头孢菌素与进口氨噻肟头孢菌素对常见致病菌的最低抑菌浓度,并着重比较8种头孢菌素抗菌作用特点。8种头孢菌素包括第一代头孢菌素噻甲酰头孢菌素与唑啉头孢菌素;第二代头孢菌素羟苄四唑头孢菌素,第三代头孢菌素氨噻肟头孢菌素、氧哌羟苯唑头孢菌
Cefotaxime (codenamed HR-756, trade name Claforan) is a new, third generation cephalosporin with broad spectrum, low toxicity, high efficiency, resistance to enzyme and easy production. 1977 was discovered by Hoechst Federal Republic of Germany and has developed into an internationally recognized and outstanding product. China in 1982 by the Sichuan Institute of antibiotics, Sichuan Changzheng Pharmaceutical Factory and Northeast Pharmaceutical Factory jointly developed. This article reports the results of in vitro antibacterial activity of domestic cefotaxime. The minimum inhibitory concentration (MIC) of domestic cefotaxime and imported cefotaxime on common pathogenic bacteria were compared, and the antibacterial effects of 8 cephalosporins were compared. 8 kinds of cephalosporins include the first-generation cephalosporins thiazole cephalosporins and azoline cephalosporins; second-generation cephalosporins cephalosporins cefepime, cefotaxime cefepime Superoxide oxypiconazole cephalosporin