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目的：探讨下肢动脉粥样硬化症（arteriosclerosis obliterans ，ASO）支架植入术后再狭窄治疗策略的可行性及安全性。方法：回顾分析2016年1月1日—2016年7月1日5例行药物球囊灌注后支架植入术及2012年6月1日—2016年7月1日15例股动脉逆行内膜剥脱术的下肢ASO支架植入术后再狭窄患者的临床资料，分析手术效果及随访期内并发症的发生情况，评价上述治疗手段的可行性、安全性。结果：20例患者行药物球囊灌注后支架植入术或股动脉逆行内膜剥脱术后，远端肢体得到充分的血流灌注，患肢皮温较前明显改善，足背动脉可触及搏动；患者自觉患肢温暖，疼痛症状明显减轻，术后随访均无再狭窄发生。结论：药物球囊灌注后支架植入术及股动脉逆行内膜剥脱术治疗下肢ASO支架植入术后再狭窄安全有效，能降低支架植入术后再狭窄的风险。“,”Objective:To analyze the effectiveness and safety of the treatment strategies for vascular restenosis after stent implantation in atherosclerosis obliterans (ASO) .Methods:The clinical data of 5 cases who had received drug‐perfused balloon from January to July in 2016 and 15 cases who had received femoral artery retrograde endarterectomy from June 2012 to July 2016 after presenting reocclusion or restenosis atherosclerosis lesions were reviewed retrospectively .The effects of surgery and complications in follow‐up period were analyzed .The effectiveness ,availability and safety of the above two methods were assessed .Results:The 20 patients had acquired an adequate blood perfusion in their distal limbs and got warmer on their feet after underwent drug‐perfused balloon and stent implantation or femoral artery retrograde endarterectomy .In addition ,they could have good palpitation in dorsal artery of feet and have better feelings on account of relieving pain .In the follow‐up ,no restenosis case had been found among them .Conclusions:The application of the stent angioplasty after using drug‐perfused balloon and femoral artery retrograde endarterectomy on vascular restenosis after stent implantation in atherosclerosis lesions proved to be effective and safe ,greatly reducing the restenosis or reocclusion frequency .