19-羟雄甾烯二酮(19-OH-AD)来自肾上腺皮质,它有盐皮质激素的作用。19-OH-AD 分泌的调节可能受促肾上腺皮质激素(ACTH)-肾上腺轴和肾素-血管紧张素系统的控制。正常人19-OH-AD 的分泌主要受 ACTH-肾上腺轴的调节。Cushing’S 病基础血浆19-OH-AD 水平升高,但其分泌机制不清,作者研究了 Cushing’S 病午夜地塞米松抑制试验和甲吡酮试验期间血浆19-OH- 19-Hydroxyandrostenedione (19-OH-AD) is derived from the adrenal cortex, which has the effect of mineralocorticoid. Regulation of 19-OH-AD secretion may be controlled by the adrenocorticotropic hormone (ACTH) -adrenal axis and the renin-angiotensin system. The secretion of 19-OH-AD in normal subjects is mainly regulated by the ACTH-adrenal axis. Cushing’S disease, basal plasma 19-OH-AD levels increased, but its secretory mechanism is unclear, the authors studied Cushing’S disease midnight dexamethasone inhibition test and metyrapone plasma levels of 19-OH-