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足月妊娠因母亲或胎儿指征需要引产十分常见。如果宫颈不成熟,则失败率高而且手术分娩及剖宫产发生率增加。主要用于软化宫颈的方法是阴道或宫颈管内放置前列腺素(PG)E_2继之静脉点滴催产素。抗孕激素米非司酮的合成为终止妊娠与引产开创了新的治疗前景,它在受体水平拮抗孕酮,增加子宫肌的活性,诱导宫颈成熟,及增进肌层对PG的敏感性。为评估米非司酮对未成熟宫颈的引产效果及新生儿状况,将参加研究的36例妇女随机分配
Full-term pregnancy due to maternal or fetal indications need induction of labor is very common. If the cervix is immature, the failure rate is high and the incidence of surgical delivery and caesarean section increases. The main method used to soften the cervix is placing prostaglandin (PG) E_2 in the vaginal or cervical canal followed by intravenous infusion of oxytocin. The synthesis of anti-progesterone mifepristone opens up new therapeutic prospects for termination of pregnancy and induction of labor. It antagonizes progesterone at the receptor level, increases uterine muscle activity, induces cervical maturation, and enhances myometrial sensitivity to PG. To evaluate the induction of labor and immature status of mifepristone in immature cervix, 36 women participating in the study were randomized