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[目的 ]探讨唾液酸化的路易斯寡糖 X(CD15s)抗原和CD4 4v6基因蛋白表达与胃癌临床病理指标和患者预后的关系。 [方法 ]应用高敏感性的催化信号放大免疫组化技术 ,对早期胃癌 17例、中期胃癌 2 1例和晚期胃癌5 7例组织进行CD15s抗原和CD4 4v6蛋白检测 ,并结合肿瘤的病理学指标和临床随访资料进行分析。 [结果 ]在胃癌中 ,CD15s和CD4 4v6的表达阳性率分别为 86 .3%和 82 .1%。且晚期胃癌明显高于早、中期胃癌 (P <0 .0 5 )。CD15s和CD4 4v6表达水平具有一致性 ,均与胃癌浆膜浸润、淋巴结转移和患者预后呈正相关 (P <0 .0 5 )。 [结论 ]CD15s和CD4 4v6表达与胃癌转移和患者生存期密切相关 ,检测CD15s和CD4 4v6的表达可作为判断胃癌预后的参考指标。
[Objective] To investigate the relationship between the expression of Sialyl Lewis X (CD15s) antigen and CD4 4v6 gene and clinicopathological parameters and prognosis of gastric cancer. [Method] With high sensitive catalytic signal amplification immunohistochemistry, CD15s antigen and CD4 4v6 protein were detected in 17 cases of early gastric cancer, 21 cases of medium-term gastric cancer and 57 cases of advanced gastric cancer. Combined with the pathological indexes And clinical follow-up data analysis. [Results] The positive rates of CD15s and CD4 4v6 in gastric cancer were 86.3% and 82.1% respectively. And advanced gastric cancer was significantly higher than the early, medium-term gastric cancer (P <0.05). CD15s and CD4 4v6 were consistent, which were all positively correlated with serosal invasion, lymph node metastasis and prognosis (P <0.05). [Conclusion] The expressions of CD15s and CD4 4v6 are closely related to the metastasis of gastric cancer and the survival of patients. Detecting the expression of CD15s and CD4 4v6 can be used as a reference index to judge the prognosis of gastric cancer.