对于抗菌药物在感染部位的分布及对其活性有重要影响的几种因素为:局部的分布除了与蛋白高度结合者外,药物常能通过被动扩散而充分透入滑液、胸膜液和其他体液中。药物透入骨内的情况较难估测,因为药物如四环素类可结合至新形成的骨质区,而在感染部位可被钙所灭活。已发现,头孢菌素Ⅰ与林可霉素在正常骨中的浓度一般低于骨髓炎者,在死骨片中并无抗菌素。曾 Antibacterial drugs for the distribution of the infection site and its activity have several important factors: Local distribution In addition to the protein with a high degree of binding, the drug can pass through the passive diffusion of the full penetration of synovial fluid, pleural fluid and other body fluids in. Drug penetration into bone is more difficult to estimate because drugs such as tetracyclines bind to newly formed bone areas and are inactivated at the site of infection by calcium. It has been found that the concentrations of cephalosporin I and lincomycin in normal bone are generally lower than osteomyelitis and that there is no antibiotic in the sequestrum. Once