【摘 要】
：
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-a
【机 构】
：
Department of Epidemiology and Health Statistics
【基金项目】
：
the National Natural Science Foundation of China
论文部分内容阅读
AIM: To clarify the influence of genetic polymorphisms on colorectal cancer.METHODS: The results of 42 related studies from 1990 to 2001 were analyzed by meta-analysis. Mantel-Haenzel fixed-effect model or Dersimonian-Laird random-effect model and ReviewManager 4.1 statistical program were applied in processing the data.RESULTS: Meta analysis of these studies showed that GSTT1 deletion (pooled OR = 1.42), N-acetyltransferase 2 (NAT2)-rapid acetylator phenotype and genotye (pooled OR = 1.08)and NAT2-rapid acetylator phenotype (pooled OR = 1.15)had a significantly increased risk for colorectal cancer (P＜0.05), other genotypes like GSTM1 deletion, GSTP1 1le105Val, NAT1*10, NAT2-rapid acetylator genotype CYP1A1 L1e462Val, CYP1A1 MspI*C, MTHFR C677T and MTR A2759G had no significant relationship with colorectal cancer (P＞0.05).CONCLUSION: Risks for colorectal cancer are significantly associated with the genetic polymorphisms of GSTT1 deletion,NAT2-rapid acetylator phenotype and genotye and NAT2-rapid acetylator phenotype.
其他文献
AIM: To study the effect of hepatitis C virus nonstructural region 3 (HCV NS3) pro, in on proliferation and transformation of normal human liver cell line.METHO
随着信息化的发展和环境的多元化,企业面对的危机压力越来越大.当面临危机时,企业如何有效化解,甚至做到“危机变转机”？本文从危机信息管理的概念入手,通过有效的危机信息管
所谓时间序列就是将某一个指标在不同时间上的不同数值,按照先后顺序排列而成的数列,它包括了系统结构特征及运行规律.本文通过时间序列分析在粮食产量预测中的应用,介绍了时
对外开放以来,我国经济迅猛发展的同时我国对外贸易尤其是出口贸易飞速增长.劳动者技术素质通过出口贸易影响我国经济增长.本文选取1986-2010年我国国内生产总值及出口总额统
项目融资自上世纪90年代引入我国以来,因具备融资比例大,有限的追索权等优点在我国受到广大投资者的青睐；因土地储备正好需要大量的持续的资金投入,这笔资金完全依靠政府财政
AIM: Hydrogen sulfide (H2S) is a prominent gaseous constituent of the gastrointestinal (GI) tract with known cytotoxic properties. Endogenous concentrations of
RNA interference (RNAi) is triggered by the presence of a double-stranded RNA (dsRNA), and results in the silencing of homologous gene expression through the sp
AIM: Expression of heat shock proteins (HSPs) is frequently up-regulated in hepatocellular carcinoma (HCC), which evolves from dysplastic nodule (DN) and early
AIM: To investigate the effect of peroxisome proliferatoractivated receptor gamma (PPAR-γ,) and its ligand,ciglitazone, on inflammatory regulation of human gal
财务预算管理在企业日常经营决策和未来发展中处于核心地位。实际工作中,财务预算管理却存在缺乏战略指导、管理体制混乱、缺乏有效监督等一系列问题。针对当前煤炭企业预算