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1例81岁女性患者因高血脂服用辛伐他汀40 mg/d治疗1年,因胆结石加用单剂量熊去氧胆酸250 mg。次日出现乏力、全身肌肉酸痛,尿色加深。第10天肌酸激酶(CK)12 650 U/L,诊断为横纹肌溶解综合征。给予患者水化治疗、静脉滴注碳酸氢钠及呋塞米治疗。期间CK最高达80 539 U/L,CK-MB/CK比值最高达7.4%。随后其症状和实验室检查逐渐恢复正常出院。
One 81-year-old female patient was treated with 40 mg of simvastatin for 1 year due to hyperlipidemia and 250 mg of ursodeoxycholic acid for a single dose of gallstone. The next day there fatigue, body aches, dark urine deepened. On day 10, creatine kinase (CK), 12 650 U / L, was diagnosed as rhabdomyolysis syndrome. Patients given hydration treatment, intravenous infusion of sodium bicarbonate and furosemide treatment. During CK up to 80 539 U / L, CK-MB / CK ratio up to 7.4%. Then its symptoms and laboratory tests gradually returned to normal discharge.