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目的研究两种剂量国产阿托伐他汀(阿乐)对介入治疗后的急性冠脉综合征(ACS)患者预后及血管内皮功能的影响。方法对97例行介入治疗后的 ACS 患者随机分为早期阿乐10mg/d(小剂量)和早期20 mg/d(大剂量)两个治疗组,1个月后根据血脂水平加减阿乐剂量。随访1年,比较两组患者血脂、内皮依赖性舒张功能(FMD)、NO、ET、总-氧化氮化合酶(NOS)、心源性死亡、急性心肌梗死、心绞痛复发、因不稳定型心绞痛住院等情况。结果治疗1、12个月时 TC、LDL-C 水平比治疗前显著降低,治疗1个月时大剂量组 TC、LDL-C 水平比小剂量组显著降低,大剂量组 NO、NO/ET 水平比治疗前显著提高。大剂量组比小剂量组1年内心绞痛复发和因不稳定心绞痛住院的发生明显减少(P<0.05)。治疗12个月时两组 FMD、TNOS 与治疗前相比均显著提高。结论早期强化降脂治疗可明显减少介入后 ACS 患者12个月内心绞痛复发和因不稳定心绞痛住院的发生率、改善患者介入治疗后 ACS 患者血管内皮功能。
Objective To study the effects of two doses of atorvastatin (Aloe) on the prognosis and endothelial function of patients with acute coronary syndrome (ACS) after interventional therapy. Methods 97 ACS patients were randomly divided into two groups: early Aloe 10mg / d (low dose) and early 20mg / d (high dose). One month later, dose. The patients were followed up for 1 year. Blood lipids, endothelium-dependent vasodilation (FMD), NO, ET, total nitric oxide synthase (NOS), cardiac death, acute myocardial infarction, angina pectoris were compared between the two groups. Hospitalization and so on. Results The levels of TC and LDL-C at 1 month and 12 months after treatment were significantly lower than those before treatment. The levels of TC and LDL-C in high-dose group were significantly lower than those in low-dose group at 1 month of treatment, while the levels of NO, NO / ET Significantly higher than before treatment. The incidence of recurrent angina pectoris and hospitalization for unstable angina in the high-dose group was significantly lower than that in the low-dose group within one year (P <0.05). At 12 months of treatment, FMD and TNOS in both groups were significantly increased compared with those before treatment. Conclusion Early lipid-lowering therapy can significantly reduce the incidence of recurrent angina pectoris and unstable angina pectoris within 12 months after PCI and improve the endothelial function of ACS patients after PCI.