肝素的生物学作用,除了能延缓血液凝固外,主要的还有:(1)能加速血中乳糜微粒(chylomicron)的消失,这可能和血浆中类似于解脂酶的酶活力增加有关(Levy 和 Swank,1955);(2)能抑制正常细胞(Paff,Sugiura,Bocher 和 Roth,1952)和瘤细胞(Lippman,1957)的分裂;(3)能和蛋白质结合成复合体(Gorger 和 Nanninga,1953);(4)能抑制许多酶的活力,如延胡索酸酶、胰蛋白酶、透明质酸酶、组织蛋白酶、核糖核酸酶、脱氧核糖核 The biological effects of heparin, in addition to slowing blood clotting, are mainly as follows: (1) it accelerates the disappearance of chylomicron in the blood, which may be related to an increase in the activity of lipase-like enzymes in plasma (Levy And Swank, 1955); (2) inhibits the division of normal cells (Paff, Sugiura, Bocher and Roth, 1952) and tumor cells (Lippman, 1957) 1953); (4) can inhibit the activity of many enzymes, such as fumarase, trypsin, hyaluronidase, cathepsin, ribonuclease, deoxyribonucleic acid