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Angew.Chem.Int.Ed.2015,54,2356~2360手性α-氨基酮是一种重要的有机合成结构构筑单元,广泛存在于具有生物活性的天然产物和药物分子中,它们的不对称化学合成往往是以对羰基化合物的不对称催化胺化来实现的.众所周知,酚及其衍生物是一类廉价、易得的化工产品,能够作为主要原料来制备多种复杂天然产物和功能材料等.西北大学化学与材料科学学院栾新军课题组依靠不对称亲电胺化策略,利用手性钪催化剂,以偶氮化合物为胺化试剂,实现了β-萘酚的不对称胺化去芳构化
Angew. Chem. Int. Ed. 2015, 54, 2356-2360 Chiral α-aminoketones are an important building block of organic synthetic structures and are widely found in biologically active natural products and drug molecules. Their asymmetry Chemical synthesis is often catalyzed by asymmetric catalysis of carbonyl compounds.It is well-known that phenols and their derivatives are a cheap and readily available chemical product that can be used as a major raw material to prepare a wide variety of complex natural products and functional materials Etc. Luan Xinjun’s group at Northwestern University School of Chemistry and Materials Science relies on the asymmetric electrophilic amination strategy to utilize the chiral scandium catalyst and the azo compound as the amination reagent to realize the asymmetric amination of β- The