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目的通过休克不同时期胱抑素C(Cys C)的含量,分析胱抑素C在婴幼儿低血容量性休克中的评价肾功能损伤情况的意义。方法因腹泻引起的低血容量性休克患儿分为休克代偿期组(37例)和失代偿期组(13例);选取30例正常体检的健康儿童作为正常对照组。通过检测血肌酐(Scr)、β2微球蛋白(β2-MG)、胱抑素C等肾功能生化指标进行对比分析。结果低血容量性休克代偿期与正常对照组Cys C比较,差异有统计学意义(t=4.17,P<0.05);β2-MG,Scr比较差异无统计意义(P>0.05);Cys C与内生肌酐清除率(Ccr)呈负相关(r=-0.86,P<0.05)。结论 Cys C作为急性肾损伤早期敏感指标其水平在婴幼儿低血容量性休克中可以提示肾脏的损伤程度。
Objective To evaluate the significance of cystatin C in assessing renal function impairment in hypovolemic shock in infants by the content of cystatin C (Cys C) in different periods of shock. Methods Children with hypovolemic shock caused by diarrhea were divided into shock-compensatory group (n = 37) and decompensated group (n = 13). 30 normal healthy children were selected as normal control group. The renal biochemical indexes such as serum creatinine (Scr), β2 microglobulin (β2-MG) and cystatin C were compared and analyzed. Results The hypovolemic shock compensatory phase was significantly different from that of the normal control group (t = 4.17, P <0.05), but there was no significant difference between the β2-MG and Scr (P> 0.05) And endogenous creatinine clearance rate (Ccr) was negatively correlated (r = -0.86, P <0.05). Conclusion Cys C as a sensitive indicator of early acute kidney injury in children with hypovolemic shock can indicate the degree of renal damage.