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二膦酸盐是一类重要的抗骨质疏松药,广泛应用于代谢性骨病和恶性肿瘤的治疗,新近被用于强直性脊柱炎。强直性脊柱炎是以T淋巴细胞和巨噬细胞浸润形成的软骨下骨炎为特点,骨质疏松为常见并发症的疾病。二膦酸盐治疗强直性脊柱炎的机制尚未明了。体外实验和关节炎的动物模型研究显示其有抗炎作用,临床试验也发现有显著疗效。二膦酸盐作用于单核/巨噬细胞系统,调节炎性因子的产生及增殖,可作为强直性脊柱炎的治疗药物。
Bisphosphonates, an important class of anti-osteoporosis drugs, are widely used in the treatment of metabolic bone diseases and malignancies and have recently been used in ankylosing spondylitis. Ankylosing spondylitis is characterized by subchondral osteitis formed by the infiltration of T lymphocytes and macrophages, a common complication of osteoporosis. The mechanism of bisphosphonates in treating ankylosing spondylitis is unclear. Animal models of in vitro and arthritis studies have shown that they have anti-inflammatory effects, clinical trials have also found a significant effect. Bisphosphonates act on the monocyte / macrophage system and regulate the production and proliferation of inflammatory cytokines, which can be used as the treatment of ankylosing spondylitis.