具有生物活性的有机磷化合物的旋光异构体在生物活性方面表现了明显的立体专一性。迄今,大多数研究工作主要集中于单手性中心的有机磷化合物。尽管含一个手性磷原子和一个手性碳原子的双手性中心的有机磷化合物的生物活性也有报道,但含双手性磷原子的旋光活性有机磷化合物却未见报道。为了研究双手性中心的混合膦(磷)酸酐的立体化学及生 Optical isomers of biologically active organophosphorus compounds show significant stereospecificity in terms of biological activity. To date, most research efforts have focused on organophosphorus compounds in the one-chiral centers. Although biological activity of organophosphorus compounds containing a chiral phosphorus atom and a bidentate center of a chiral carbon atom has also been reported, optically active organophosphorus compounds containing bifunctional phosphorus atoms have not been reported. In order to study the stereochemistry and biogenesis of mixed phosphine (P) anhydrides in bisected centers