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目的:探讨布拉氏酵母菌对婴幼儿期下呼吸道感染患儿抗生素应用中腹泻的预防作用。方法:216例应用抗生素治疗的下呼吸道感染患儿随机分成两组,一组114例(预防组)同时服用布拉氏酵母菌,另一组102例(对照组)开始不用任何微生态制剂,出现腹泻后加服布拉氏酵母菌,比较两组腹泻的发生率,疗效,腹泻持续时间以及腹泻疗程并进行统计分析。结果:预防组继发腹泻22例,发病率19.29%;对照组腹泻39例,发病率为38.24%。预防组患儿腹泻持续时间(3.14±0.86)d,对照组患儿腹泻持续时间(4.58±0.91)d;预防组腹泻疗程(4.09±1.11)d,对照组腹泻疗程(6.47±1.10)d,两组腹泻持续时间、腹泻疗程比较差异有统计学意义(t=6.06,8.16,P均<0.01)。结论:布拉氏酵母菌能降低婴幼儿期下呼吸道感染患儿抗生素应用中腹泻的发病率,早期应用可缩短腹泻持续时间和疗程,利于患儿康复。
Objective: To investigate the preventive effect of B. Cerevisiae on diarrhea in antibiotics in infants with lower respiratory tract infection. Methods: A total of 216 children with lower respiratory tract infection treated with antibiotics were randomly divided into two groups. One group of 114 patients (prophylaxis group) took B. saccharomyces while the other 102 patients (control group) did not need any probiotics. After adding diarrhea plus Saccharomyces boulardii, the incidence of diarrhea, efficacy, duration of diarrhea and diarrhea were compared between two groups and analyzed statistically. Results: There were 22 cases of secondary diarrhea in prevention group, the incidence rate was 19.29%. The control group was diarrhea in 39 cases with the incidence of 38.24%. The duration of diarrhea in control group was (3.14 ± 0.86) d, the duration of diarrhea in control group was (4.58 ± 0.91) d, the duration of diarrhea in prevention group was (4.09 ± 1.11) d, the duration of diarrhea in control group was (6.47 ± 1.10) The duration of diarrhea and diarrhea between the two groups showed statistically significant differences (t = 6.06, 8.16, P <0.01). CONCLUSIONS: B. Cerevisiae can reduce the incidence of diarrhea during antibiotic use in infants with lower respiratory tract infection. Early application can shorten the duration and course of diarrhea, which will benefit the recovery of children.