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目的探讨≥80岁患者应用他汀降脂的效果和安全性。方法选择我院≥80岁的血脂异常患者96人,随机分配为阿托伐他汀组(50人)及辛伐他汀组(46人)治疗1年。观察指标有肝肾功能、血脂等指标。结果辛伐他汀组总有效率为85.12%,阿托伐他汀组总有效率为95.15%,两组间比较有统计学差异(P<0.05)。两组治疗前后比较总胆固醇(CHO)、甘油三酯(TG)及低密度脂蛋白(LDL-C)、高密度脂蛋白(HDL-C),差异均有统计学意义(P<0.05)。而谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)、肌酐(Cr)、空腹血糖(GLU),差异无统计学意义(P>0.05)。结论他汀用于≥80岁的患者安全有效,阿托伐他汀具有更好的安全性优势。
Objective To investigate the effect and safety of statin lipid lowering in patients over 80 years old. Methods 96 patients with dyslipidemia who were 80 years or older in our hospital were randomly assigned to atorvastatin group (50 persons) and simvastatin group (46 persons) for one year. Observed indicators of liver and kidney function, blood lipids and other indicators. Results The total effective rate was 85.12% in simvastatin group and 95.15% in atorvastatin group, with statistical significance (P <0.05). Before and after treatment, the differences of total cholesterol (CHO), triglyceride (TG), low density lipoprotein (LDL-C) and high density lipoprotein (HDL-C) were statistically significant (P <0.05). ALT, AST, CK, Cr and fasting blood glucose (GLU) showed no significant difference (P> 0.05). Conclusions Statins are safe and effective for patients ≥80 years of age. Atorvastatin has a better safety profile.