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用生化分析的方法对6例手术切除并证实为胰外分泌腺癌及其2例正常组织中糖胺聚糖的含量和组成成份进行对比分析。结果发现：①糖胺聚糖的合量癌组织显著高于正常胰腺组织；②双向电泳分析正常胰腺组织出现三条区带，为硫酸皮肤素、透明质酸和硫酸乙酰肝素，胰腺癌组织出现四条区带，除上述三种区带外还有明显的硫酸软骨素带；③超微结构示胰腺癌组织明显纤维化，肿瘤易玻坏基底膜向问质内浸润。结果提示在胰腺癌发生及发展中癌细胞和间质中糖胺聚糖的代谢和表达发生了显著的变化。
The content and composition of glycosaminoglycans in 6 cases of pancreatic exocrine adenocarcinoma and 2 cases of normal tissues were analyzed by biochemical analysis. The results showed that: 1 The amount of glycosaminoglycans in cancer tissues was significantly higher than that in normal pancreatic tissues; 2Drawings of normal pancreas showed three bands with two-dimensional electrophoresis: dermatan sulfate, hyaluronic acid, and heparan sulfate. Four pancreatic cancer tissues appeared. Zones, in addition to the three zones above, there are significant chondroitin sulfate bands; 3 ultrastructure showed significant fibrosis of pancreatic cancer tissue, tumors tend to Bose basement membrane infiltration into the quality of the interstitial. The results suggest that there is a significant change in the metabolism and expression of glycosaminoglycans in cancer cells and interstitium during the development and progression of pancreatic cancer.