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目的探讨慢性阻塞性肺疾病(COPD)患者血清抵抗素、瘦素水平及其与营养状况的关系。方法用酶联免疫吸附测定(ELISA)和放射免疫法检测57例稳定期COPD患者和31名健康对照者血清抵抗素、瘦素水平,分析相关因素。结果COPD患者血清抵抗素、瘦素水平[(2·1±1·2)、(0·65±0·41)μg/L]与对照组[(3·6±2·3)、(1·03±0·71)μg/L]比较差异均有统计学意义(P均<0·01)。COPD营养不良患者抵抗素、瘦素水平[(1·7±0·7)、(0·43±0·16)μg/L]显著低于非营养不良患者[(2·2±1·2)、(0·73±0·48)μg/L,P均<0·05]。COPD患者抵抗素与瘦素、第一秒用力呼气容积(FEV1)及FEV1/用力肺活量(FVC)显著正相关(r=0.426~0.531,P均<0·01),瘦素与体重指数(BMI)、胸围、腹围、抵抗素及FEV1/FVC显著正相关(r=0.371~0.580,P均<0·01)。结论COPD稳定期患者血清抵抗素、瘦素水平下降,合并营养不良时下降更显著。
Objective To investigate the relationship between serum resistin, leptin and nutritional status in patients with chronic obstructive pulmonary disease (COPD). Methods The serum levels of resistin and leptin in 57 stable COPD patients and 31 healthy controls were detected by enzyme-linked immunosorbent assay (ELISA) and radioimmunoassay. Relevant factors were analyzed. Results Serum levels of resistin and leptin in COPD patients were significantly higher than those in control group [(2 · 1 ± 1 · 2), (0 · 65 ± 0 · 41) μg / L] [(3 · 6 ± 2 · 3) · 03 ± 0 · 71) μg / L], there were significant differences (all P <0.01). The levels of resistin and leptin in patients with COPD malnutrition were significantly lower than those in non-malnutrition patients ([(1.7 ± 0.7) and (0.043 ± 0.16) μg / L, respectively] [(2.2 ± 1.2 ), (0.73 ± 0.48) μg / L, all P <0.05]. The levels of leptin, FEV1 and FEV1 / FVC in patients with COPD were significantly and positively correlated (r = 0.426-0.531, P <0.01), while those of leptin and body mass index BMI), chest circumference, abdominal circumference, resistin and FEV1 / FVC (r = 0.371-0.580, all P <0.01). Conclusion The serum levels of resistin and leptin in patients with stable COPD are declining, and the decline is more significant when malnutrition is combined.