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目的：研究半夏泻心口服液对实验性慢性胃炎的作用机理。方法：以半夏泻心口服液对乙醇及脱氧胆酸钠诱发的实验性慢性胃炎大鼠进行治疗，疗程结束后用放免法检测大鼠血浆ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ１ɑ水平。结果：半夏泻心口服液能显著降低血浆ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ１ɑ，两者比值亦下降。结论：半夏泻心口服液治疗慢性胃炎的机制可能与调整ＴＸＢ２和６－Ｋｅｔｏ－ＰＧＦ１ɑ的动态平衡，改善胃粘膜微循环，增加胃粘膜氧、能供应有关。
Objective: To study the mechanism of action of Banxia Xiexin Oral Liquid on experimental chronic gastritis. METHODS: Rats with experimental chronic gastritis induced by ethanol and sodium deoxycholate were treated with Banxia Xiexin Oral Liquid. Plasma levels of TXB2 and 6-Keto-PGF1ɑ were measured by radioimmunoassay after the end of treatment. Results: Banxia Xiexin Oral Liquid can significantly reduce plasma TXB2 and 6-Keto-PGF1ɑ, and their ratios also decreased. Conclusion: The mechanism of treatment of chronic gastritis with Banxia Xiexin Oral Liquid may be related to adjusting the dynamic balance of TXB2 and 6-Keto-PGF1ɑ, improving the microcirculation of gastric mucosa and increasing the oxygen and energy supply of gastric mucosa.