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目的分析乌灵胶囊联合阿立哌唑治疗儿童抽动障碍的效果。方法选取2013年6月-2014年6月滨州医学院附属医院就诊的儿童抽动障碍患者88例,随机分为对照组和治疗组,每组各44例。对照组采用阿立哌唑进行治疗,治疗组在对照组基础上加用乌灵胶囊治疗。采用耶鲁评分表(YGTSS)和注意力缺陷多动障碍(ADHD)评分量表评价两组治疗效果。结果治疗组患儿治疗后发声抽动[(2.92±1.14)分]、运动抽动[(8.94±3.41)分]、功能受损程度[(7.48±5.46)分]、抽动总评分[(10.26±3.28)分]均低于对照组[(4.49±3.01)分、(10.31±3.13)分、(10.26±7.35)分、(13.44±5.38)分],差异均有统计学意义(P<0.05);多动冲动[(3.91±2.22)分]、注意力缺陷[(6.23±3.64)分]、ADHD总分[(10.31±3.13)分]均低于对照组[(6.84±3.14)分、(7.04±4.53)分、(13.29±5.21)分],差异均有统计学意义(P<0.05);治疗组总有效率为86.36%(38/44),明显高于对照组(70.45%,31/44),差异有统计学意义(P<0.05)。结论乌灵胶囊联合阿立哌唑治疗儿童抽动障碍可明显降低YGTSS和ADHD评分,效果优于单用阿立哌唑治疗。
Objective To analyze the effect of Wuling capsule combined with aripiprazole on children with tic disorder. Methods Seventy eight children with tic disorder admitted to Affiliated Hospital of Binzhou Medical College from June 2013 to June 2014 were randomly divided into control group and treatment group, 44 cases in each group. The control group was treated with aripiprazole. The treatment group was treated with Wuling capsules on the basis of the control group. The Yale Rating Scale (YGTSS) and Attention Deficit Hyperactivity Disorder (ADHD) Rating Scale were used to evaluate the effect of treatment. Results After treatment, the patients in the treatment group had twitch [(2.92 ± 1.14) points, motor twitch (8.94 ± 3.41), degree of functional impairment (7.48 ± 5.46), total tic [10.26 ± 3.28 ) Were lower than that in the control group [(4.49 ± 3.01), (10.31 ± 3.13), (10.26 ± 7.35), (13.44 ± 5.38)], respectively, with statistical significance (P <0.05) (3.91 ± 2.22), ADHD (6.23 ± 3.64), ADHD score (10.31 ± 3.13) were lower than those in the control group (6.84 ± 3.14), (7.04 ± 4.53), (13.29 ± 5.21), respectively, the differences were statistically significant (P <0.05). The total effective rate was 86.36% (38/44) in the treatment group, which was significantly higher than that in the control group (70.45%, 31 / 44), the difference was statistically significant (P <0.05). Conclusion Wuling capsules combined with aripiprazole in children with tic disorder can significantly reduce the YGTSS and ADHD scores, the effect is better than the single aripiprazole treatment.