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作者研究了活动性类风湿性关节炎患者尿中唾液酸-三糖排泄量。经鉴定尿中排出的是唾液酸-乳糖和唾液酸-半乳糖甙-(β_1-4)-N-乙酸氨基葡萄糖,应用薄层和气相色谱法检查两者的排泄量。结果:6例活动性类风湿性关节炎患者尿唾液酸-乳糖排泄量为48.2±6.1mg/24小时,5例健康人的排泄量为19.8±3.7mg/24小时,8例其他结缔组织疾病(骨关节炎、关节周围炎、系统性红斑狼疮)患者的排泄量为16.6±2.4mg/24小时,类风湿组的唾液酸-乳糖排泄量明显(p <0.01)高于后两组。
The authors studied urinary sialic acid-trisaccharide excretion in patients with active rheumatoid arthritis. It was identified that sialic acid-lactose and sialyl-galactoside- (βl-4) -N-acetylglucosamine were excreted in urine, and the excretion of both was examined by thin layer and gas chromatography. Results: The urinary sialic acid-lactose excretion of 6 patients with active rheumatoid arthritis was 48.2 ± 6.1 mg / 24 hours, the excretion of 5 healthy persons was 19.8 ± 3.7 mg / 24 hours, and 8 other connective tissue diseases (Arthritis, periarthritis, systemic lupus erythematosus) was 16.6 ± 2.4 mg / 24 hours, and the sialic acid-lactose excretion was significantly higher in the rheumatoid group (p <0.01) than in the latter two groups.