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肠易激综合征(irritable bowel syndrome,IBS)是一种常见的以腹痛或腹部不适伴排便习惯改变为特征的慢性功能性肠病,西方国家发病率为15%～20%,北京地区约为7%。其缺乏形态学和生物化学改变的标志,其病因和发病机制迄今尚不明确,多年来国内外学者对其易感因素进行了大量研究,从最早的肠道平滑肌功能障碍学说,逐渐发展到内脏痛觉过敏学说,然后发展到脑-肠轴学说,等等。目前的研究主要集中在精神心理、肠道动力、神经内分泌、免疫及环境等因素方面。1 精神心理因素与 IBS精神心理因素被广泛认为是 IBS 致病的—个易感
Irritable bowel syndrome (IBS) is a common chronic functional bowel disease characterized by changes in abdominal pain or abdominal discomfort associated with bowel movements. The incidence in Western countries is 15% -20%, while that in Beijing is approximately 7%. The lack of morphological and biochemical changes in the sign, the etiology and pathogenesis has not yet clear, over the years of domestic and foreign scholars have conducted a lot of its susceptibility factors, from the earliest theory of intestinal smooth muscle dysfunction, and gradually evolved to the internal organs The hyperalgesia theory then develops into the brain-gut axis theory, and so on. The current research mainly focuses on the aspects of mental psychology, intestinal motility, neuroendocrine, immune and environmental factors. 1 Psychosocial Factors and IBS Psychosocial Factors Are Widely Recognized as IBS-Susceptible