虽然雌激素缺乏和骨丢失之间的关联性早已为人所知,但其发生机制尚不清楚。一项新的研究发现,这种关联由破骨细胞里的硫醇抗氧化剂所介导。在机体的其他部位可见到雌激素抑制活性氧核素(ROS),后者已知具有刺激破骨细胞的作用。因此,雌激素缺乏很可能有助于刺激破骨细胞,从而促进骨质的丢失。当雌激素缺乏时,抗氧化剂水平明显较低。来自于英国伦敦圣乔治医学 Although the association between estrogen deficiency and bone loss has long been known, the mechanism is still unclear. A new study found that this association is mediated by thiol antioxidants in osteoclasts. Estrogen inhibits reactive oxygen species (ROS), which are known to stimulate osteoclasts, in other parts of the body. Therefore, estrogen deficiency is likely to help stimulate osteoclasts, thereby contributing to the loss of bone mass. Antioxidant levels were significantly lower when estrogen was deficient. From St. George’s Medicine in London, England