为了探讨肺癌中ｎｍ２３基因产物核苷二磷酸激酶的表达及其临床意义，应用免疫组化方法（ＳＰ法）检测肺癌组织标本中ｎｍ２３基因产物核苷二磷酸激酶的表达．结果，ｎｍ２３基因产物核苷二磷酸激酶在肺癌中表达阳性率为５４％，其中鳞癌４２％，腺癌６９％，两者有显著差别．ｎｍ２３基因产物核苷二磷酸激酶表达与肺鳞癌有无淋巴结转移显著相关，与肺腺癌有无淋巴结转移无显著相关性．ｎｍ２３基因可能在不同类型肺癌的形成和转移过程中起不同的调节作用，在肺鳞癌淋巴结转移过程中发挥负性调控作用 To investigate the expression of nucleoside diphosphate kinase of nm23 gene in lung cancer and its clinical significance, immunohistochemistry (SP method) was used to detect the expression of nucleoside diphosphate kinase in nm23 gene in lung cancer. Results, nm23 gene product nucleoside diphosphate kinase in lung cancer expression was 54%, of which 42% squamous cell carcinoma, adenocarcinoma 69%, a significant difference between the two. nm23 gene product nucleoside diphosphate kinase expression of lung squamous cell carcinoma with or without lymph node metastasis was significantly correlated with lymph node metastasis of lung adenocarcinoma no significant correlation. The nm23 gene may play a different regulatory role in the formation and metastasis of different types of lung cancer and play a negative regulatory role in lymph node metastasis of squamous cell lung cancer