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自由基是具有一个不配对电子的原子和原子团的总称。由氧诱发者称氧自由基或活性氧,主要指超氧阴离子·O_2~-和羟自由基·OH~-及单线态氧。H_2O_2非自由基,但氧化作用很强,通常并包括在自由基中。氧自由基与多聚不饱和脂肪酸作用后生成烷自由基(L·)、烷氧自由基(LO·)、烷过氧自由基(LOO·)等属脂性自由基。自由基性质极活泼,具有强烈的引发脂质过氧化作用。生理情况下,由于红细胞内有超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH—PX)等抗氧化酶类存在能及时清除自由基,故于机体无害;病理条件下,由于活性氧产生过多或抗自由基酶类活性降低,可引发链式脂质过氧化反
Free radicals are a collective term for atoms and radicals that have an unpaired electron. Oxygen-induced oxygen induced by oxygen or reactive oxygen species, mainly refers to the superoxide anion · O 2 ~ - and hydroxyl radicals · OH ~ - and singlet oxygen. H 2 O 2 is not a free radical, but is strongly oxidized, usually and included in free radicals. Oxygen free radicals and polyunsaturated fatty acids produce alkyl free radicals (L ·), alkoxy free radicals (LO ·), alkyl peroxy radicals (LOO ·) and other lipid free radicals. Extremely lively nature of free radicals, with a strong trigger lipid peroxidation. Under physiological conditions, free radicals are eliminated in time due to the presence of antioxidant enzymes such as superoxide dismutase (SOD) and glutathione peroxidase (GSH-PX) in erythrocytes, which are harmless to the body. Pathological conditions , Due to excessive production of reactive oxygen species or anti-free radical activity decreased, can trigger chain lipid peroxidation