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肿瘤发生与染色体畸变相关的证据最初来自对染色体断裂综合征的细胞遗传学研究.该疾病个体的细胞在体外培养时,其染色体断裂和重排率均明显增高.这种染色体改变在Bloom综合征(BS)、Fanconi贫血和共济失调性毛细血管扩张症中都是自发产生的,而在着色性干皮病中则由特殊的DNA损伤物质诱发.由于该类患者恶性肿瘤的发病风险远高于正常人,所以人们推论这类患者体内细胞同样具有染色体不稳定的特点,对此已获得一些间接证据,但迄今缺乏直接证据.本文报道了检查口腔粘膜、尿
Evidence related to chromosomal aberrations in tumorigenesis originally came from the cytogenetic study of chromosomal breakage syndrome. The chromosomes of individuals with this disease have an apparent increase in chromosome breakage and rearrangement rate when cultured in vitro. This chromosomal alteration is in Bloom syndrome. (BS), Fanconi anemia, and ataxia telangiectasia are all spontaneous, and in pigmented xeroderma disease they are induced by specific DNA damaging substances. Because of the high risk of malignancy in this group of patients. In normal people, so people deduced that the cells in these patients also have the characteristics of chromosomal instability, which has obtained some indirect evidence, but there is no direct evidence so far. This article reports on the examination of oral mucosa, urine