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目的探讨右旋糖酐铁口服液联合维生素C治疗儿童缺铁性贫血的临床疗效。方法选取2015年1月-2015年12月黄岩区妇幼保健院收治的92例缺铁性贫血患儿为研究对象,采用随机数字列表法分为观察组(46例,右旋糖酐铁口服液+维生素C)与对照组(46例,硫酸亚铁口服液+维生素C),两组患儿均治疗3个月,比较临床疗效及治疗前后血红蛋白(Hb)、红细胞平均容量(MCH)平均血红蛋白浓度(MCHC)表达水平,并记录与治疗相关的不良反应发生情况。结果治疗后观察组总有效率为93.48%,对照组为67.39%,两组比较,差异有统计学意义(χ~2=4.090,P=0.043)。治疗前,观察组与对照组患儿Hb、HCV、MCHC表达水平比较,差异无统计学意义(t=0.220、0.190、0.120,P=0.830、0.850、0.910);治疗后观察组患儿Hb(t=56.110,P=0.000)、HCV(t=15.170,P=0.000)、MCHC(t=37.900,P=0.000)表达升高,对照组患儿Hb(t=8.770,P=0.000)、HCV(t=10.110,P=0.000)、MCHC(t=5.940,P=0.000)表达升高,观察组患儿Hb(t=6.520,P=0.000)、HCV(t=5.930,P=0.000)、MCHC(t=2.250,P=0.027)表达水平高于对照组。治疗后,观察组患儿的不良反应发生率为4.35%,对照组为17.49%,观察组患儿不良反应发生率显著低于对照组(χ~2=4.040,P=0.044)。结论缺铁性贫血患儿服用右旋糖酐铁联合维生素C治疗方案临床疗效优于传统的铁剂补充药物,能显著改善贫血的临床症,疗效确切,安全可靠。
Objective To investigate the clinical efficacy of dextran oral liquid combined with vitamin C in children with iron-deficiency anemia. Methods From January 2015 to December 2015, 92 children with iron-deficiency anemia admitted in Huangyan District Maternal and Child Health Hospital were divided into observation group (46 cases, iron dextran + vitamin C ) And control group (46 cases, ferrous sulfate oral solution + vitamin C). Both groups were treated for 3 months. The clinical curative effect and the mean hemoglobin (Hb), the mean hemoglobin concentration (MCHC) ) Expression, and record the incidence of adverse reactions associated with treatment. Results After treatment, the total effective rate was 93.48% in the observation group and 67.39% in the control group. There was significant difference between the two groups (χ ~ 2 = 4.090, P = 0.043). Before treatment, the expression levels of Hb, HCV and MCHC in observation group and control group had no significant difference (t = 0.220,0.190,0.120, P = 0.830,0.850,0.910); after treatment, Hb ( The levels of HCV (t = 15.170, P = 0.000) and MCHC (t = 37.900, P = 0.000) The levels of Hb (t = 6.520, P = 0.000) and HCV (t = 5.930, P = 0.000) in the observation group were significantly higher than those in the control group (t = 10.110, MCHC (t = 2.250, P = 0.027) higher than the control group. After treatment, the incidence of adverse reactions was 4.35% in the observation group and 17.49% in the control group. The incidence of adverse reactions in the observation group was significantly lower than that in the control group (χ ~ 2 = 4.040, P = 0.044). Conclusion The clinical efficacy of iron dextran combined with vitamin C in children with iron-deficiency anemia is better than that of traditional iron-supplemented drugs and can significantly improve the clinical symptoms of anemia. The curative effect is safe and reliable.