论文部分内容阅读
目的探讨肾黏液小管状和梭形细胞癌(MTSCC)的临床病理特征以及鉴别诊断。方法观察1例肾MTSCC的临床表现、组织学特征和免疫組化,并复习相关文献。结果患者女性,64岁。体检发现右肾占位。病理检查见右肾下极一个大小5.5 cm×4.7 cm×3.5 cm的肿物;切面为实性、灰白色,与周围肾组织界限较清晰。镜下肿瘤由紧密排列的狭长小管及梭形细胞样结构构成,间质为淡染的黏液样基质,瘤细胞立方形,细胞核圆形或卵圆形,核仁小或不明显,无明显异型性,核分裂象少见,未见坏死。瘤细胞广谱CK、CK7、EMA、34βE12和vimentin(+),P504S灶状(+)。结论 MTSCC是一种罕见的肿瘤,可以在典型的组织表现基础上出现其他非特异性改变,了解MTSCC各种形态上的变异,有助于对其做出正确的诊断。
Objective To investigate the clinicopathological characteristics and differential diagnosis of renal mucinous tubulointerstitial and spindle cell carcinoma (MTSCC). Methods The clinical manifestations, histological features and immunohistochemistry of one case of renal MTSCC were observed and the related literatures were reviewed. Results Patient female, 64 years old. Physical examination found right kidney occupancy. Pathological examination, see the right lower pole of a size of 5.5 cm × 4.7 cm × 3.5 cm of the tumor; section is solid, gray, and the surrounding renal tissue boundaries more clearly. Microscopically, the tumor consisted of narrowly arranged tubules and spindle-like cell-like structures. The stroma was a light-stained myxoid-like stroma. The tumor cells were cuboidal, with a round or ovoid nucleus, little or no nucleoli, Sexual, mitotic rare, no necrosis. Broad spectrum of tumor cells CK, CK7, EMA, 34βE12 and vimentin (+), P504S (+). Conclusions MTSCC is a rare tumor which can show other nonspecific changes based on the typical histological findings. It is helpful to know the various morphological variations of MTSCC and make the correct diagnosis.